The Trojans were shaky on defense in a 42-28 win over Arizona State. Now, two of the best signal-callers in the nation vie as Colorado's Shedeur Sanders faces reigning Heisman Trophy winner Caleb Williams of USC. 8 USC -24 at Colorado: The Buffaloes' agenda took a devastating hit after losing 42-6 to Oregon in a game that, amazingly, wasn't even as close as the final score. Auburn might simply not have the talent to hang after scoring 24 points in two games against power-conference opponents, but coach Hugh Freeze typically gets up for big games. Georgia was tied 7-7 against UAB 20 minutes into the game last week and faced a 14-3 halftime deficit against South Carolina. 1 Georgia -16 at Auburn: The Bulldogs don't face many challenges this season, but a trip to Jordan-Hare Stadium in Auburn, Alabama, always opens the door to weirdness. The Fighting Irish look the part of a CFP team so far, but that will be put to the test against Duke's Mike Elko, a former Notre Dame defensive coordinator. Notre Dame lost a heartbreaker against Ohio State and now has to travel for the high-intensity matchup. The Blue Devils are beating the heck out of opponents, topping their first four by a combined 114 points, and averaging more than 200 yards rushing per game.

17 Duke: All eyes are on Durham, North Carolina, in Week 5, just like we expected. A loss for either team makes a SEC West title chase more difficult. Ole Miss blew a halftime lead against Alabama in a 24-10 decision, wasting perhaps Lane Kiffin's best chance to beat his former boss, Nick Saban. The Tigers gave up 31 points and needed a late field goal to survive an upset bid against Arkansas. 20 Ole Miss: The pair could have been better in Week 4, but they face a critical rebound opportunity in Oxford, Mississippi.

Kansas is among the final three undefeated programs in the Big 12 behind the exploits of star quarterback Jalon Daniels, but the Longhorns present one of the most fearsome defenses in the conference after holding their first four opponents to a combined 50 points. 3 Texas -17: The Longhorns host the pesky Jayhawks for the final time as conference mates, but for the first time in 22 games, both teams enter ranked.

Oregon State returns home after losing a tight 38-35 loss to Washington State, setting up a pivotal matchup in Corvallis, Oregon, for the Pac-12 race. Utah could get starting quarterback Cameron Rising back for the matchup against the Beavers, who remain a legitimate Pac-12 contender. 19 Oregon State -1.5: The Utes have their first conference road test after starting 4-0. Odds via SportsLine consensus The big games

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